Kategorie: Posts In EnglishSeite 1 von 5

Gut microbes eat our medication

Researchers have discovered one of the first concrete examples of how the microbiome can interfere with a drug’s intended path through the body. Focusing on levodopa (L-dopa), the… (weiter lesen)

Gut Bacteria Affect Metabolism of Levodopa

Levodopa, one of the main medicines used to treat Parkinson’s symptoms, can be converted into dopamine by gut bacteria, researchers report. The findings might explain why levodopa treatment… (weiter lesen)

Gut bacterial tyrosine decarboxylases restrict levels of levodopa

Abstract: Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In this study, we characterize… (weiter lesen)

Journal of Parkinson’s Disease

https://content.iospress.com/journals/journal-of-parkinsons-disease/Pre-press/Pre-press The Journal of Parkinson’s Disease is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that will expedite our… (weiter lesen)

Physical Activity and Parkinson Disease Risk

Fang et al1 reported a meta-analysis of prospective studies to determine whether there is evidence of a quantitative dose-response association between physical activity and Parkinson disease (PD) risk.… (weiter lesen)

A Call to Action to Improve Patient Care

Experts propose ways to address the rapidly rising number of deaths from Parkinson’s disease and related disorders and improve the end of life care of Parkinson patients in… (weiter lesen)

Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease

Abstract Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which… (weiter lesen)

LRRK2 activation in idiopathic Parkinson’s disease

New proximity ligation assays were developed and validated As a LRRK2 autophosphorylation site, pSer1292 reflects the activity of LRRK2 per se. We developed a proximity ligation assay to… (weiter lesen)

Neurophysiological correlates of bradykinesia

Abstract Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson’s disease. However, it is unclear whether there is any relationship between them… (weiter lesen)

Rescuing Suboptimal Outcomes of Subthalamic Deep Brain Stimulation

Abstract BACKGROUND Clinical trials have established subthalamic deep-brain-stimulation (STN-DBS) as a highly effective treatment for motor symptoms of Parkinson disease (PD), but in clinical practice outcomes are variable.… (weiter lesen)