Die entzündliche Darmkrankheit Morbus Crohn und die degenerative Hirnerkrankung Morbus Parkinson haben eine gemeinsame genetische Wurzel. Untersuchungen in Science Translational Medicine (2018; 10: eaai7795) zeigen, dass Varianten im Gen LRRK2 die Häufigkeit beider Erkrankungen beeinflussen. Weiterlesen
Researchers get their first look at how the toxic protein clusters associated with Parkinson’s disease disrupt the membranes of healthy brain cells. In new research, scientists have characterised the key agents involved in spreading Parkinson’s disease in the brain, and established how they ‘drill’ into the walls of healthy brain cells (neurons). Weiterlesen
Loss of function mutations of DJ-1 (PARK7) have been linked to the pathogenesis of Parkinson disease (PD). Antioxidative stress is one of the multi-protective functions of DJ-1, and oxidation of cysteine 106 (Cys106) has been proposed to regulate the protective activity of DJ-1. Uncoupling protein 4 (UCP4) is located in the inner membrane of mitochondria and functions to protect against oxidative stress. Weiterlesen
A recent study by The Scripps Research Institute, in the journal ‘Cell Reports’, shows how a process in nerve cells called the S-nitrosylation (SNO) reaction – which can be caused by ageing, pesticides and pollution – may contribute to Parkinson’s disease. Weiterlesen
Mutations in DNAJC13 gene have been linked to familial form of Parkinson’s disease (PD) with Lewy pathology. DNAJC13 is an endosome-related protein and believed to regulate endosomal membrane trafficking. However, the mechanistic link between DNAJC13 mutation and α-synuclein (αSYN) pathology toward neurodegeneration remains poorly understood. Weiterlesen
Der Pharmakonzern Pfizer will sich bei der Forschung neu aufstellen. Wie das US-Unternehmen am Wochenende mitteilte, stellt es sein Programm zur Entwicklung neuer Mittel gegen Alzheimer und Parkinson ein. Das eingesparte Geld will es künftig dort ausgeben, wo die Aussichten und die Erfahrung am größten sind. Weiterlesen
Summary: A new study reveals Parkinson’s patients have more copies of mitochondrial DNA in the brain stem, leading to increased cell death within that area.
Source: Newcastle University.
Experts at Newcastle and Sussex universities also revealed that surviving brain cells in the brainstem have more copies of mitochondrial DNA and this has not been identified before. Weiterlesen
Alzheimer’s disease is caused by the build-up of two abnormal proteins, beta-amyloid and tau. Tau is particularly important because it causes neurons and their connections to die, preventing brain regions from communicating with each other normally. In the majority of cases, tau pathology first appears in the memory centres of the brain, known as the entorhinal cortex and hippocampal formation. This has been shown to occur many years before patients have any symptoms of disease. Weiterlesen
Swedish scientists tested a cocktail of molecules in mice with Parkinson-like symptoms.
After treatment, the mice’s symptoms appeared to improve.
The revolutionary approach may overtake brain cell transplants, which was previously thought to be the only hope of a cure.
According to study author Dr Ernest Arenas, this new treatment will not require the immune system-suppressing drugs needed in transplants.
The therapy makes dopamine-producing cells from those already in the brain, meaning patients will not reject them, which is a risk with transplants, he said. Weiterlesen