Kategorie: Posts In EnglishSeite 1 von 5

Journal of Parkinson’s Disease

https://content.iospress.com/journals/journal-of-parkinsons-disease/Pre-press/Pre-press The Journal of Parkinson’s Disease is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that will expedite our… (weiter lesen)

Physical Activity and Parkinson Disease Risk

Fang et al1 reported a meta-analysis of prospective studies to determine whether there is evidence of a quantitative dose-response association between physical activity and Parkinson disease (PD) risk.… (weiter lesen)

A Call to Action to Improve Patient Care

Experts propose ways to address the rapidly rising number of deaths from Parkinson’s disease and related disorders and improve the end of life care of Parkinson patients in… (weiter lesen)

Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease

Abstract Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which… (weiter lesen)

LRRK2 activation in idiopathic Parkinson’s disease

New proximity ligation assays were developed and validated As a LRRK2 autophosphorylation site, pSer1292 reflects the activity of LRRK2 per se. We developed a proximity ligation assay to… (weiter lesen)

Neurophysiological correlates of bradykinesia

Abstract Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson’s disease. However, it is unclear whether there is any relationship between them… (weiter lesen)

Rescuing Suboptimal Outcomes of Subthalamic Deep Brain Stimulation

Abstract BACKGROUND Clinical trials have established subthalamic deep-brain-stimulation (STN-DBS) as a highly effective treatment for motor symptoms of Parkinson disease (PD), but in clinical practice outcomes are variable.… (weiter lesen)

The Role and Development of the Antagonist of Adenosine A2A

Adenosine is a neuromodulator that regulates the body’s response to dopamine and another neurotransmitter in the brain that is responsible for motoric, emotion, learning, and memory function. Adenosine… (weiter lesen)

Gene Therapeutic Strategies for Neuroprotection

Gene transfer methodologies are being explored as strategies to restore and preserve neuronal function in Parkinson’s Disease. This technology represents a new therapeutic modality, holding promise for continuous… (weiter lesen)

Parkinson’s Disease: A Looming Pandemic

New research shows that the number of people with Parkinson’s disease will soon grow to pandemic proportions.  In a commentary appearing today in the journal JAMA Neurology, University… (weiter lesen)